Friday, May 1, 2020

Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update



Coronavirus Pandemic Update 64: Remdesivir COVID-19 Treatment Update

91,138 views
Apr 30, 2020
COVID-19 Update 64 with critical care specialist and pulmonologist Roger Seheult, MD on Remdesivir treatment trial updates.

Dr. Seheult breaks down two studies on remdesivir that were released yesterday. One remdesivir study was published in the Lancet (the study was conducted in China) and the other was published by the NIH (the study was conducted in the United States). The results of these studies on remdesivir coronavirus treatment vs placebo were dramatically different.

Links referenced in this video:

Johns Hopkins -
https://coronavirus.jhu.edu/map.html

NIH -
https://www.nih.gov/news-events/news-...

The Lancet -
https://www.thelancet.com/action/show...

Some previous videos from this series (visit MedCram.com for the full series):
-Coronavirus Pandemic Update 63: Is COVID-19 a Disease of the Endothelium (Blood Vessels and Clots)?
https://youtu.be/Aj2vB_VITXQ
- Coronavirus Pandemic Update 62: Treatment with Famotidine (Pepcid)?
https://youtu.be/DtPwfihjyrY
- Coronavirus Pandemic Update 61: Blood Clots & Strokes in COVID-19; ACE-2 Receptor; Oxidative Stress
https://youtu.be/22Bn8jsGI54
- Coronavirus Pandemic Update 60: Hydroxychloroquine Update; NYC Data; How Widespread is COVID-19?
https://youtu.be/fn2yk5SbGiw
- Coronavirus Pandemic Update 59: Dr. Seheult's Daily Regimen (Vitamin D, C, Zinc, Quercetin, NAC)
https://youtu.be/NM2A2xNLWR4
- Coronavirus Pandemic Update 58: Testing; Causes of Hypoxemia in COVID-19 (V/Q vs Shunt vs Diffusion)
https://youtu.be/nO4xgcIaPeA
- Coronavirus Pandemic Update 57: Remdesivir Treatment Update and Can Far-UVC Disinfect Public Spaces?
https://youtu.be/2U4DAQ3kjRs
- Coronavirus Pandemic Update 56: What is “Forest Bathing” & Can It Boost Immunity Against Viruses?
https://youtu.be/PgDjVEpEOdQ
- Coronavirus Pandemic Update 55: How COVID-19 Infection Attacks The Immune System & Differs From HIV:
https://youtu.be/8NffZAGELGg
- Coronavirus Pandemic Update 54: COVID-19 Antibody vs. PCR Testing; When to Relax Social Distancing?:
https://youtu.be/kgzFAdYwYLM
- Coronavirus Pandemic Update 53: Anticoagulation; Can Mechanical Ventilation Make COVID 19 Worse?:
https://youtu.be/o8aG63yigjA
- Coronavirus Pandemic Update 52: Ivermectin Treatment; Does COVID-19 Attack Hemoglobin?:
https://youtu.be/qc6VV7ue4cE
- Coronavirus Pandemic Update 51: State by State Projections; Ultrasound to Diagnose COVID19 Pneumonia:
https://youtu.be/E7MufS6dnJw
- Coronavirus Pandemic Update 50: Dip in Daily New Deaths; Research on Natural Killer Cells & COVID-19:
https://youtu.be/fya6Zwxch88
- Coronavirus Pandemic Update 49: New Data on COVID-19 vs Other Viral Infections (Ventilator Outcomes):
https://youtu.be/uaIzj3s3p4A
- Coronavirus Pandemic Update 48: Curve Flattening in California, PPE in the ICU, Medication Trials:
https://youtu.be/JN-8bGB1cLM
- How Coronavirus Kills: Acute Respiratory Distress Syndrome (ARDS) & Treatment:
https://youtu.be/okg7uq_HrhQ

Many other videos on COVID-19 (coronavirus outbreak, coronavirus symptoms, influenza, coronavirus epidemic, corona virus updates, coronavirus vaccine, boosting the immune system, vitamin D, vitamin C, Zinc, Quercetin, NAC, n-acetyl cysteine, Insomnia, PPE, hydroxychloroquine, ultrasound to diagnose COVID-19, coronavirus New York, COVID-19 and the epithelium/blood vessels) and other medical topics (ECG Interpretation, strokes, thrombosis, pulmonary embolism, myocardial infarction, hypercoagulation, hypertension, anticoagulation, DKA, acute kidney injury, influenza, measles, mechanical ventilation, etc.) at MedCam.com

Speaker: Roger Seheult, MD
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.

MedCram provides videos to a variety of medical schools, education programs, and institutions (please contact us at customers@medcram.com if you are interested)

Media Contact: customers@medcram.com
Media contact info:
https://www.medcram.com/pages/media-c...

MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor.
#COVID19 #SARSCoV2 #Coronavirus

Friday 1st May Comorbidities and symptoms report



Friday 1st May Comorbidities and symptoms report

46,615 views
May 1, 2020
656K subscribers
SUBSCRIBED
Risk factors and clinical features
https://www.imperial.ac.uk/news/19721...
https://www.medrxiv.org/content/10.11...

Features of 16,749 hospitalised UK patients with COVID-19 (Imperial college, 28th April)
Prospective observational cohort study
The largest detailed description of COVID-19 in Europe
166 UK hospitals
6th February to18th April 2020

N = 16,749 people hospitalised with COVID-19
This represents 14.7% of all people who have tested positive for COVID-19 in the UK
239 patients (2.0%) under 18 years
139 patients (1.1%) are under 5 years of age
Men 60.2%, women 39.8%
Results
Median age 72 years
IQR 57 – 82
Median duration of symptoms before admission was 4 days
IQR 1- 8
Median duration of hospital stay 7 days

Commonest comorbidities
Chronic cardiac disease, 29%
Uncomplicated diabetes, 19%
Non-asthmatic chronic pulmonary disease, 19%
Asthma, 14%
No documented reported comorbidity, 47%

Increased age and comorbidities including obesity were associated with a higher probability of mortality

Clinical features
Cough, 70%
Fever 69%
Shortness of breath 65%
High degree of overlap between the three common symptoms
Reported no symptoms, 4%
Clusters of symptoms were found
1. The most common symptom cluster encompass the respiratory system: cough, sputum, shortness of breath, fever, sore throat, runny nose, ear pain, wheeze, chest pain
2. Musculoskeletal symptoms: myalgia, joint pain and fatigue
3. Enteric symptoms: abdominal pain, vomiting and diarrhoea
29% of all patients complained of enteric symptoms on admission, mostly in association with respiratory symptoms
4% of all patients described enteric symptoms alone.
Outcomes
49% discharged alive
33% died
17% continued to receive care

17% required admission to High Dependency or Intensive Care Units
of these
31% were discharged alive
45% died
24% continued to receive care

Of those receiving mechanical ventilation,
20% were discharged alive
53% died
27% remained in hospital
Pregnant women 6%
Pregnancy was not associated with mortality, in apparent contrast with influenza

Friday 1st May, Global Update



Friday 1st May, Global Update

7,616 views
May 1, 2020
Dr. John Campbell
656K subscribers
SUBSCRIBED
COVID – 19, Friday 1st May

US president, has seen evidence that coronavirus originated at the Wuhan Institute of Virology

Office of the director of national intelligence, the Intelligence Community also concurs with the wide scientific consensus that the Covid-19 virus was not manmade or genetically modified

WHO
Investigation of origins of coronavirus
WHO not invited by China

Virus arrival time
Italy, Feb 25th
Portugal, March 20th
Hungary, March 21st

UK
Deaths + 674 = 26, 840
Oxford vaccine trial, now using several UK centres
Astra Zeneca
Google reports more moving around last weekend

US
Cases: 1,069,866
Deaths: 63,014

New York cases: 304,372
New York deaths: 23,587

Georgia
To lift state-wide shelter-in-place order for most residents starting tomorrow
Brian Kemp, order remained for elderly medically fragile
Urged residents to still stay at home as much as possible

I went to Petco this morning, not one employee or customer had a mask on. Nor were there any efforts to maintain social distancing.

Australia
App
Doesn't track your location or use any kind of geolocation
Uses Bluetooth to "ping" the phones of people around you who have the app installed
Stores that info with encryption for a rolling period of 21 days to allow for the incubation time of the virus
After the 21 days the data is erased
Personal info is encrypted on the phone and a unique ID is generated and tied to that user
If someone develops symptoms or tests positive, contacts are known
Contacts informed and advise them to self-isolation for 14 days. Here's a link to more information.

Germany
Cases,
Friday + 1,639
Thursday + 1,478
Wednesday 29th + 1,600
Tuesday 28th + 1,200
Monday 27th + 988 Lockdown eased on 27th
Sunday 26th + 1,300
Titration

Singapore
Cases, + 932 = 17,101

Most among migrant workers, living in dormitory complexes

Just 5 new cases in Singapore nationals
Deaths, 15

South Africa
Lockdown 10 days after the first case
Early lockdown worked
Infections will now increase
Starting to ease lockdown
Townships sharing toilets
Weakened by corruption

India
Locked down for 6 weeks
Stringent controls
Checkpoints around the country
Spread greatly slowed
New Delhi, red zones identified
Lockdown ending soon

France
Repairing bicycles
Temporary bike parking spaces
Reduce overcrowding in metros and buses
Employers to cover up to 400 euros of travel costs of staff who cycle to work
Cycling can contribute to preventing a second wave of the coronavirus pandemic
Planning to create new bike lanes by taking space away from car lanes

Russia
Record daily rise again
Friday + 7, 933 = 114,431
Thursday + 7,099
Deaths + 101 + 93 = 1,69
Deaths doubles in last 8 days
Not yet a peak
People restricted to homes
Lockdown to May 11th

Brazil
Deaths + 345
Hospitals overwhelmed
Long way to the peak
Stigma
Limited testing
Sao Paulo, digging 13,000 graves

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