Friday, January 1, 2021

Hundreds of Covid vaccine doses 'intentionally' destroyed at Wisconsin hospital NBC Universal ELIZABETH CHUCK AND MATTEO MOSCHELLA AND BEN KESSLEN December 31, 2020, 5:16 PM

 

Hundreds of Covid vaccine doses 'intentionally' destroyed at Wisconsin hospital

ELIZABETH CHUCK AND MATTEO MOSCHELLA AND BEN KESSLEN
 
 
 
 

A Wisconsin hospital employee has been fired and arrested after removing dozens of vials of the coronavirus vaccine from a pharmacy refrigerator, intentionally destroying more than 500 doses, a hospital investigation found.

The incident happened over the weekend at the Aurora Medical Center in Grafton, north of Milwaukee. Grafton police announced the arrest of the pharmacist Thursday, but did not name the man or identify a motive.

Police said in a statement they arrested the former employee on suspicion of recklessly endangering safety, adulterating a prescription drug and criminal damage to property. The damage he caused "was estimated to be between $8,000 and $11,000," police said.

Initially, it appeared that the 57 vials of the Moderna vaccine — which must be kept between 36 and 46 degrees Fahrenheit — had been left out overnight accidentally, hospital officials said. Each vial holds approximately 10 doses of the vaccine.

But Wednesday, the Aurora Medical Center announced the hospital worker involved "acknowledged that they intentionally removed the vaccine from refrigeration."

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Aurora Medical Center in Grafton, Wis. (Google Maps)
Aurora Medical Center in Grafton, Wis. (Google Maps)

"We continue to believe that vaccination is our way out of the pandemic. We are more than disappointed," the hospital said in a statement, adding that the employee has been terminated. "This was a violation of our core values."

The Moderna vaccine has a 12-hour window once it has been thawed. Most doses of the vaccine that had been left out of the pharmacy refrigerator had to be discarded, although hospital officials later believed they could salvage some. After the hospital administered more than 50 doses of the vaccines that had been thawed, it learned the shots had actually been thawed twice, rendering them ineffective, a hospital official said Thursday at a press conference. The hospital said all those who received an ineffective vaccination have been notified and that those individuals are not at risk.

News of the spoiled vaccine doses in Wisconsin comes as the United States struggles to meet its goals for vaccination. So far, only about 2.8 million people have been vaccinated, far short of the 20 million the Trump administration had hoped for by year-end.

The vaccine is not yet widely available, and health care workers and nursing home residents have priority for the first doses.

On Wednesday, Advocate Aurora Health, the health system that Aurora Medical Center is part of, said it has vaccinated more than 21,000 health care workers so far.

The pharmacist is currently being held at Ozaukee County Jail.



UK variant linked to high viral loads, Neanderthal gene offers protection Reuters NANCY LAPID December 31, 2020, 7:20 PM

 

UK variant linked to high viral loads, Neanderthal gene offers protection

NANCY LAPID
 
 
 
 

By Nancy Lapid

(Reuters) - The following is a roundup of some of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

UK coronavirus variant associated with higher viral loads

The highly infectious COVID-19 coronavirus variant that has been circulating in Britain is linked to higher loads of the virus in swab samples obtained from the nose and the back of the throat, according to a research report published on medRxiv on Sunday ahead of peer review. Around 35% of patients infected by the variant form had very high levels of the virus in their samples, compared to 10% of patients without the variant, study leader Michael Kidd of Public Health England and Birmingham University told Reuters. Higher viral loads have been linked with worse COVID-19 outcomes. The tests were conducted at the Birmingham Turnkey Lab. Kidd said additional study was needed to confirm or refute the findings. If confirmed, he hopes scientists will investigate how this particular variant manages to make more copies of itself in infected patients. (https://bit.ly/3nUEJrr)


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Neanderthal gene protects against COVID-19

A specific form of a protein passed down from Neanderthals protects against severe COVID-19, and medications that boost levels of this protein could potentially help treat the disease, according to a study reported on medRxiv on Thursday ahead of peer review. The protein, called OAS1, is involved in the body's response to viruses. People with higher levels of the Neanderthal-related form of OAS1 are less susceptible to COVID-19, and if they do become infected, they are at lower risk for hospitalization, intubation and death, the researchers found. "This protective form of OAS1 is present in sub-Saharan Africans but was lost when the ancestors of modern-day Europeans migrated out of Africa. It was then re-introduced into the European population through mating with Neanderthals" who lived more than 40,000 years ago, said coauthor Brent Richards from the Jewish General Hospital and McGill University in Montreal. An earlier study linked a cluster of genes inherited from Neanderthals to higher risks of hospitalization from COVID-19. "These findings further implicate Neanderthal ancestry in COVID-19 severity," Richards said. (https://bit.ly/2KxrQVP)

Early antibody production key to COVID-19 recovery

The speed of patients' antibody production - rather than the volume of antibodies they produce to fight the new coronavirus - determines whether they will survive COVID-19, new data suggest. Researchers who studied more than 200 COVID-19 patients, including 179 who were hospitalized, found those who produced so-called neutralizing antibodies within 14 days of developing symptoms eventually recovered, while those who did not produce neutralizing antibodies until more than 14 days had elapsed developed higher viral loads and more severe disease. "It is unclear why antibodies generated after this time point are unable to promote viral clearance and recovery in COVID-19 patients," the researchers said in a report posted on medRxiv ahead of peer review. Study leader Akiko Iwasaki of the Yale University School of Medicine tweeted on Saturday, "It's possible that virus somehow becomes resistant by hiding in inaccessible tissues." The new findings, she added, suggest therapy with so-called monoclonal antibody drugs - such as those from Regeneron given to U.S. President Donald Trump -- is likely to work only if used soon after infection. (https://bit.ly/3pv6qaB)

Open https://tmsnrt.rs/3a5EyDh in an external browser for a Reuters graphic on vaccines and treatments in development.

(Reporting by Nancy Lapid; Editing by Tiffany Wu)

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